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  • Synergy CBD: Most Effective Products From Top Brands Of 2022

Written by The Hemp Jubilation Team

Updated on: February 21, 2022

We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. Here's our process.

Synergy CBD refers to the interaction between cannabinoids, terpenes, and flavonoids that work together for a greater effect.

Cannabinoids are naturally occurring chemical compounds that are found in cannabis as well as hemp plants. Common cannabinoids besides CBD include THC, CBC, CBG, CBN and offer much more promising results when taken together.

Terpenes are aromatic compounds found in plants, including cannabis. When terpenes work with cannabinoids like CBD and THC, they form a synergy that creates stronger and better effects than both would achieve on their own.

Flavonoids are known for their antioxidant and anti-inflammatory health benefits providing painkilling properties that aren’t available from just terpenes and cannabinoids alone.

Many CBD brands are creating hemp-derived products combining the power of THC, CBC, CBG, CBN, terpenes, and flavonoids. Scientists and companies are learning and discovering when consumed together, Synergy CBD products might enhance a greater effect.

Most Effective Synergy CBD Brands To Shop Of 2022 Quick Links

To choose the best Synergy CBD products of 2022, the Hemp Jubilation team researched and analyzed brands and products made from plants grown in the U.S.

All have a certificate of analysis (COA), are third-party tested by ISO 17025-compliant laboratories, and contain no more than 0.3% THC.

From effectiveness, price, quality, value to potency to flavor options, to reading real user reviews and the quality of customer service, see which Synergy CBD product stands out as your favorite pick.

Most Effective Synergy CBD

Most Effective Synergy CBD Five CBD Full Spectrum CBDTHC Gummies 1

Five CBD Full Spectrum CBD+THC Gummies


  • Certified Current Good Manufacturing Practice (cGMP)
  • Highest quality CBD+THC extract with up to 6x the minor cannabinoids of its competitors
  • Potent and effective
  • Ease your pain, calm your mind, relax and sleep better
  • Gummies are vegan (pectin based) and contain all-natural ingredients
  • Over 350 Five Star Reviews from real customers
  • Offers frequent CBD sales and discounts on its website

Five CBD is best known for the Entourage Effect which is a synergistic relationship and response pattern where all of the beneficial cannabinoids work together to assist in executing their functions and potential enhanced benefits.

Best Synergy CBD Reviewed

Most Effective Synergy CBD:

1. Five CBD Full Spectrum CBD+THC

Product Description:

Five CBD is a safe and reputable brand providing some of the best quality, high potency authentic full-spectrum products at affordable prices.

Five CBD Full Spectrum CBD+THC product types tinctures, gummies, capsules, and chocolates.

If you use a Five CBD product, you’re getting a genuine, fully-powered, complete full-spectrum CBD experience sourced from the best hemp farms in the US.

The Fab product line consists of only 4 CBD product types tinctures, gummies, capsules, and chocolates. All of their items are packed with minor cannabinoids and terpenes and contain approximately 2mg of THC per milliliter.

Except for the Daily Buzz full-spectrum gummies with 25mg of CBD and 5mg of THC. This is a higher level of THC than traditional CBD gummies and you may feel a slight buzz from these.

These gummies are vegan (pectin-based) and contain all-natural ingredients and come in Flavors: Orange, Blue Razz, Citrus, Lime, Mixed Berry, and Red Raspberry.

The full-spectrum CBD+THC Oil is available in 2 different flavors (citrus and mint chocolate) and 3 different potencies.

Products are produced in five's AA Rated BRC facility which is the highest rating for food manufacturing. In addition to quality manufacturing, the brand continues its commitment to being transparent by providing up-to-date third-party lab testing on all its products located on the Lab Results page of its website.

To view the lab results for a particular product, just find it on this page and click View Certificate. While cannabinoid and terpene levels can vary slightly from batch to batch, they will be representative of the product that you purchase.

This is an outstanding product for anyone who wants carefully crafted formulas that leverage the CBD effect to its fullest potential and are about as natural and genuine as Synergy CBD products get. 

They also offer free shipping on all orders. And if you are not satisfied with your product, you may request a refund of the full purchase price, minus shipping costs, within 30 days of the product received date.

Pros:

  • All products have a 5:1 ratio of CBD to other major cannabinoids
  • Packed with minor cannabinoids and terpenes to create products that can deliver real results
  • Fully powered full-spectrum formulation
  • Most potent in minor cannabinoids products on the market
  • 6x the minor cannabinoids of its competitors
  • CBD products you can feel
  • Affordable pricing makes FIVE CBD ideal for just about everyone
  • Free shipping with no order minimum

Cons:

  • Product selection isn’t the most versatile
  • No information about who is behind the company
  • Not the best customer service

Five CBD Reviews by Users

The vast majority of customers have great things to say about Five CBD in their reviews. You will notice a lot of people commenting on the best CBD/THC gummies I have ever tried. I would highly recommend. They taste great and they do their job way better than any other. Great price and fast shipping. 

Use code HEMPJUBILATION for 15% off at checkout. 


Benefit Ingredients That Enhance Synergy:

2. CBDistillery Synergy Collection

Product Description:

CBDistillery has established itself as one of the most popular, trusted, and reputable brands in the industry. 

Synergy CBD From CBDistillery Product Collection

Also Read: Our Full CBDistillery Review

CBDistillery has earned its popularity by being focused on the things that customers care about the most. These include product effectiveness, quality, safety, affordable prices, and third-party lab testing.

This unique Synergy CBD collection of hemp cannabinoids with other functional ingredients in CBD Synergy products is unlike anything else on the market. These products go beyond just CBD alone to provide maximum health and wellness benefits.

They are specially formulated with other powerful cannabinoids including CBG, CBN and CBDA, terpenes, and flavonoids. Some items also include enhancing natural ingredients such as functional mushrooms and kava root. 

Each category in the CBDistillery's new Synergy Collection supports a variety of CBD products specially formulated to promote health and wellness benefits based on your needs. Categories include Raw Synergy, Daytime Synergy, Sleep Synergy, Wellness Synergy, and Calm Synergy.

We only recommend brands that do extensive third-party lab testing of their products and make those reports easily accessible for customers. Third-party lab testing of each product batch is one of the most important things to look for. It’s really the only way to know what’s in the product and that it’s safe.

The brand posts up-to-date third-party lab reports on each product page of its website to ensure you receive the highest-quality CBD guaranteed. You can also access a copy of lab results for your specific product’s batch by scanning the QR code using your smartphone.

CBDistillery’s prices are among the lowest available on the market. Their high-quality products and affordable prices make them an excellent choice for those looking for safety, great value, and a large selection of Synergy CBD products based on your needs.

They also have free shipping on orders over $75 along with having a 60-day money-back guarantee on all products if you are dissatisfied for any reason.

Pros:

  • High-quality CBD derived from naturally grown hemp
  • Non-GMO industrial hemp that has been grown in the U.S
  • Intense purification and potency testing process that guarantees an extremely safe product
  • Transparency on another level
  • Excellent prices for such high-end Synergy CBD products
  • Effective variations for both daytime and nighttime needs

Cons:

  • Refund response rate. Some commented that it takes time to get your refund (if you decide to ask for one).
  • Some customers cite shipping delays

CBDistillery Reviews by Users

CBDistillery has over 37,000 5-Star reviews by real users that are shown on each product page of the official website.

These reviews will help potential buyers be more informed about the effectiveness of the product, benefits, and whether or not they have good customer service which is important when choosing a brand to shop for. This information will help you find the Synergy CBD product that is best for you.

Use code MYCBD for 15% off at checkout.


Best Quality: 

3. NuLeaf Naturals Full Spectrum Multicannabinoid CBD Collection

Product Description:

NuLeaf Naturals is one of America’s number one CBD brands to shop. Its products are definitely made with quality and care. 

NuLeaf Naturals Full Spectrum Multicannabinoid CBD Collection

Also Read: Our Full NuLeaf Naturals Review

NuLeaf Naturals is a reliable, safe, and legit brand for Synergy CBD, with a nice variety of Multicannabinoid product offerings.

When it comes to the highest-grade organic hemp grown in the United States and Green extraction practices, NuLeaf shines above most other brands.

Why? Because the cannabinoids in its products are extracted with advanced methods to obtain an entire range of synergistic cannabinoids, terpenes, essential oils, and other beneficial phytonutrients. This produces a more potent, desirable blend that requires no harsh solvents.

NuLeaf's Multicannabinoid CBD oil and Capsules provides the most powerful and absorbable products using zero additives, preservatives, or artificial sweeteners.

This incredible Multicannabinoid product takes everything we love about full-spectrum CBD and amplifies it with a highly concentrated balanced blend of the most widely known cannabinoids CBC, CBD, CBG, CBN.

The brand is committed to transparency and third-party lab testing to ensure safe, consistent, and effective products. 

A copy of up-to-date lab test results can be accessed through a link on the product pages of their website. It includes a full set of lab results, including the cannabinoid profile, terpenes profile, and results of testing for residual solvents, pesticides, and heavy metals.

NuLeaf's prices are not among the lowest available online. However, it is one of the highest-quality full-spectrum products on today's market.

This is a tremendous product for anyone who truly wants to supercharge the effectiveness of the CBD for balanced wellness, stress and anxiety, pain and arthritis, and better sleep.

They offer fast and free shipping to anywhere in the United States along with having a 30-day money-back guarantee on all unused, and unopened products. They do ask that you pay to ship for these returns.

Pros:

  • Organic Colorado-grown hemp in ISO-certified facilities with certified Good Manufacturing Practices (cGMP)
  • Noticeably higher quality
  • Provide superior products that are potent and effective
  • Potential to change your life for the better
  • Exceptional customer service available 7 days a week
  • Free priority shipping

Cons:

  • Some users dislike the earthy taste of natural CBD drops and NuLeaf does not offer flavor options
  • CBD products are limited to CBD oils and CBD capsules

NuLeaf Naturals Reviews by Users

NuLeaf Naturals has over 25,000 5-Star reviews by real users that are shown on each product page of the official website.

It seems that several customers of all ages have great things to say about NuLeaf Naturals Multicannabinoid products in their reviews, like, This product really works folks. Fantastic service experience. The product arrived very quickly. It is THE most potent CBD I have had. I find it more effective than CBD alone.

Use code HempJubilation for 20% off at checkout.


High Levels Of All-Natural Terpenes: 

4. CBD American Shaman CBD & Terpenes Collection

Product Description:

American Shaman is one of the more reputable and established CBD brands in the industry having been founded in 2015. Since then they've developed a strong reputation for high-quality CBD products.

CBD American Shaman CBD & Terpenes Synergy CBD Product Collection

CBD American Shaman is all about embracing holistic health through ultra-concentrated terpene-rich CBD oil derived from all-natural, high-quality industrial hemp to enhance your CBD beneficial experience and provide some of the tastiest tinctures. 

The brand offers these oils in five flavor options: Natural Flavored, Strawberry Banana, Blueberry Moon, Cinnamon, and Grape. It comes with four different strength options and they also offer both full-spectrum and THC-free products.

The brand says that they use a unique proprietary nanotechnology to enhance products by 9x more bioavailability than anything else on the market and create a better product. However, there is no scientific evidence to back it up.

CBD American Shaman claims that all its products undergo both internal lab testing and third-party testing to ensure that they are providing only the best products for its customers.

You will find a link to the test results on each product page. But, at the time of this review, some lab test results appeared to be outdated.

This is a good product for anyone who wants a strong terpene profile that promotes focus, happiness, calm, motivation, and full-body relief all-day long.

They offer free shipping with $99 orders to anywhere in the United States along with if you are not satisfied, they will refund your order within 45 days if purchased from their official website. 

Pros:

  • Uses a unique nanotechnology approach to extraction that is expected to be faster and more efficiently absorbed by the body
  • One of the largest and most diverse product lines on the market
  • Available in full spectrum (less than 0.3% THC) or THC free
  • Products are made with terpene-rich CBD oil
  • 100% organic, gluten-free, non-GMO

Cons:

  • Very little information on the founding members, and the company itself
  • The brand’s proprietary nanotechnology has not been scientifically proven to increase absorption
  • Complete lab test reports not available on the brand website and some appear to be outdated

CBD American Shaman Reviews by Users

Generally speaking, most customers seemed pretty much pleased by the American Shaman’s CBD & Terpenes products. Saying the oils work fabulously! Would recommend this product to everyone. The flavors were good, mild on the tongue, and overall complementary to the experience.

The effects of the products seemed good enough for most customers to opt for monthly subscriptions. The brand’s customer service has also been widely appreciated by quite a few buyers. Saying the staff and company are one of the best I found. 


Highest Potency & Award-Winning Flavors: 

5. Fab CBD Oil Full Spectrum Blends

Product Description:

The Fab CBD brand has built a reputation of trustworthiness, customer-friendly staff, and the production of high-quality Synergy CBD products driven by science and attention to customer needs.

Fab CBD Oil Full Spectrum in a variety of natural flavors including citrus, mint, natural, berry, and vanilla.

Also Read: Our Full Fab CBD Review

With high potency products and award-winning flavors at affordable prices, this CBD company almost seems too good to be true. But, for the most part, FAB CBD is as high quality as they get.

Why? Because the company sells a limited number of products compared to some other brands. With a smaller product line, they can focus more on quality over quantity.

Fab CBD Oil is the brand’s most popular product crafted with high concentrates of full-spectrum extracts keeping the naturally occurring terpenes and other beneficial cannabinoids in place. 

These tinctures are expertly formulated to deliver not only a desirable consistency but a variety of natural flavors that your taste buds will love including citrus, mint, natural, berry, and vanilla, and strengths up to 2400mgs to give you exactly what you need. 

The brand is very transparent about the safety and potency of its products. They post up-to-date third-party lab reports on each product page of its website to ensure that their products are 100% pure, are full of beneficial cannabinoids and terpenes, and have no traces of pesticides or heavy metals. 

This is a superb product for anyone who wants a CBD oil to provide a more well-rounded experience to give your mind and body what it deserves through not just one cannabinoid, but through many to experience all over relaxation, stress relief, exceptional pain relief, and powerful sleeping aid.

Fab CBD offers free shipping on orders of $99 or more. And if you’re not satisfied with the products, there’s a 30-day refund policy you can turn to.

Now, if you find the Fab CBD products to be effective, you can earn points when buying them. For each dollar you spend, you’ll get 5x points which you can use for discounts and future purchases.

Pros:

  • Well-formulated cannabinoid and terpenes CBD oil product line
  • High concentrates of a full-spectrum extract
  • Delivers appealing consistency
  • No unpleasant artificial flavoring
  • Easy to use dropper design
  • Customers get consistently top-notch customer service
  • FAB CBD’s prices are comparable or more affordable

Cons:

  • Sold out easily
  • Some customers have complained about slow shipping 
  • There is very little information on the people behind the brand

Fab CBD Reviews by Users

There are more than 1,000 Fab CBD oil reviews from satisfied customers. And the majority of these reviews are 5-stars. Several customers wrote about the unbeatable prices, exceptional customer service, and loved how they felt after consuming this Fab CBD product.


Best CBD Plus THC: 

6. Medterra CBD True Full Spectrum

Product Description:

Medterra is an industry-leading brand that exceeds high standards for product quality, lab testing, and customer service.

Medterra’s True Full Spectrum CBD oil comes in two flavors, citrus, and chocolate mint.

Also Read: Our Full Medterra CBD Review

When you purchase True Full-Spectrum CBD+THC products from this company, you can be assured that you’re getting a superior quality product from a safe and reputable brand that has received overwhelmingly positive reviews from customers who use and trust their products.

Powerful and effective, the Medterra full spectrum tinctures contain all of the cannabinoids, terpenes, and flavonoids present in the whole plant.

They include a natural balance of CBD, CBG, CBN, CBC, and 2mg THC. The addition of THC enhances the effects of the cannabinoid for an impressive, more powerful experience every time.

Each serving of Medterra's True Full Spectrum CBD contains 50 milligrams of CBD, 2 milligrams of THC, and 8 milligrams of other cannabinoids. One of the best ways to experience the enhanced effects of synergy CBD and feel better.

Medterra’s True Full Spectrum CBD oil comes in two flavors, citrus, and chocolate mint. And I have to say that the chocolate mint tastes great in the morning when paired with some hot coffee.

The brand's True Full Spectrum line also includes gummies and capsules. Both methods are super for convenient and consistent dosing on the go.

All of Medterra's hemp extracts go through independent, third-party lab testing so that you can be sure you’re receiving the safest, highest quality product and ensure THC levels are below the legal limit of .3% THC (by weight).

As always, their Certificates of Analysis or testing results are always available for review on the website's product page.

In terms of pricing, the cost of Medterra’s products is quite reasonable. And their company is one of the top CBD companies online.

Because they are made up of highly educated and credentialed individuals, including a board-certified dermatologist, pharmacist, a medical doctor, and a veterinarian who help research, formulate and create the brand's CBD products.

This is an impressive product for anyone who wants the full benefits of the hemp plant from one of the most trusted brands in the industry for enhanced relaxation, sleep, recovery, and well-being.

Customers can select various shipping options at the Medterra checkout. Medterra states that it offers a full refund on new, unopened items, minus shipping, to anyone unsatisfied with products who requests a refund within 30 days of delivery.

Pros:

  • U.S. Hemp Authority Certified. This certification means the brand is committed to using high-quality CBD in its products.
  • Committed to quality
  • Professional expertise. The company employs medical experts to help with product formulation
  • An industry-leading 5:1 ratio of CBD to other cannabinoids and terpenes
  • Transparent and reliable brand
  • Respect rules for accurate and clear labeling

Cons:

  • No official organic certification
  • Some complaints about bad shipping experiences
  • No discount programs

Medterra CBD Reviews by Users

Medterra’s website features over 8,000 customer reviews, with an average rating of 4.6 stars out of 5. A typical example includes positive comments about product quality and a description of how the products work great for specific health conditions.

Use code OFFER15 for 15% off at checkout.


Benefits Of Cannabinoids, Terpenes & Flavonoids

THC is another main cannabinoid found in Cannabis Sativa plants. THC is the compound that produces the intoxicating, psychoactive “high” often associated with cannabis.

However, when CBD and THC are consumed together, CBD binds to the receptors and blocks THC from binding with them, thus lessening some of the effects felt by the THC.

Full-spectrum CBD has trace amounts of THC. However, the concentration of THC in full-spectrum CBD oil should be no more than 0.3%. Such small amounts won’t get you high.

THC and CBD are a match made in heaven. THC and CBD combine to offer comprehensive benefits that neither could accomplish alone. And the therapeutic benefits of CBD are possibly amplified by the presence of even a little THC.

CBC is commonly associated with pain-killing effects, improved mood, and neuroprotection. However, the research in the matter of CBC’s benefits is still limited.

CBG is another cannabinoid with promising therapeutic applications. CBG is known to have antibacterial, antifungal, and antiparasitic properties. It has also shown promise as an anticancer compound that inhibits the growth of cancer cells.  

CBN: While there is not nearly as much research into CBN as there is for other cannabinoids, the limited evidence available suggests that CBN may have several health and wellness benefits.

CBN may be a potent antibacterial agent, may also be a powerful neuroprotectant, and it could be an effective appetite stimulant. CBN is also believed to decrease anxiety and improve levels of relaxation.

Terpenes seem to support the capabilities of cannabinoids thanks to synergy. Synergy refers to the unique effects that occur when different plant compounds are administered together. Terpenes seem to enhance the body’s ability to absorb and utilize cannabinoids to their fullest potential.

Flavonoids play an important role alongside terpenes in inducing the entourage effect. This is the theory that the compounds in cannabis work together, and when taken together, they produce a better effect than when taken alone.

Final Thoughts About Synergy CBD

Without a doubt, cannabinoids, terpenes, and flavonoids boast tons of properties that can enhance your daily routine and promote a sense of wellbeing throughout the body and mind.

However, when consumed individually, these compounds each have significant therapeutic benefits. But, when consumed together, their beneficial capacity is synergistically enhanced.

This means you could see even greater therapeutic benefits when using Synergy CBD products that contain a combination of cannabinoids, terpenes, and flavonoids rather than CBD on its own.

Now that you know how fascinating cannabinoids, terpenes, and flavonoids are, you can seek out products that incorporate all these compounds into their formulas for a better likelihood of reaching your wellness goals.

In this Synergy CBD article, we’ve listed the best brands to shop for 2022. Any one of these Synergy CBD reviews is going to give you a more well-rounded hemp experience while also providing a slew of other health benefits. Do consult a doctor before giving yourself any supplement.


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